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Nilsson Group
Resources

Publications

At the University of Rochester

Exploring the Holdase Activity of Supramolecular Chaperones with Amyloid-Forming Peptides and Insulin.

Piedmont, E. R.; Distaffen, H. E.; Crompton, L. C.; Krauss, T. D.; Nilsson, B. L.; Partridge, B. E.

Biomacromolecules 2026. DOI: https://doi.org/10.1021/acs.biomac.5c02408.

Comparison of Pleated and Rippled β-Sheet Assembly of Sequence Isomers of an Amphipathic Self-Assembling Peptide

Jones, C.W.; Chen, J.; Panda, R.; Jalali, S.; Cardani, L.P.; Guo, Y.; Arnold, I.M.; Dias, C.L.; Nilsson, B.L.

Biochemistry 2026, DOI: http://10.1021/acs.biochem.6c00035

Effect of pH on the Emergent Viscoelastic Properties of Cationic Phenylalanine-Derived Supramolecular Hydrogels

Agredo, P.; Ghosh, S.; Abraham, B.L.; Nilsson, B.L.

Gels 2025, 11(11), 877; DOI: https://doi.org/10.3390/gels11110877

Self-Assembly Properties of Xylene-Derived Constitutional Isomers of Fmoc-Phenylalanine

Agredo, P.; Mohan, R.; Carter, S. T.; Nilsson, B. L.

Langmuir 2025, 41, 38, 25962–25969. DOI: 10.1021/acs.langmuir.5c02581

Multicomponent supramolecular hydrogels composed of cationic phenylalanine derivatives and anionic amino acids

Ghosh, S.; Distaffen, H. E.; Jones, C. W.; Nilsson, B. L.

Faraday Discuss. 2025, 260, 260-376, DOI: 10.1039/D4FD00198B

Insights into Membrane Damage by α-Helical and β-Sheet Peptides. 

Rangubpit, W.; Distaffen, H. E.; Nilsson, B. L.; Dias, C. L.

Biomolecules 2025, 15, 973. DOI: 10.3390/biom15070973 

Multicomponent Supramolecular Hydrogels Composed of Cationic Phenylalanine Derivatives and Anionic Amino Acids

Ghosh, S.; Distaffen, H.E.; Jones, C.W.; Nilsson, B.L.

Faraday Discuss., 2024, DOI: 10.1039/D4FD00198B

Pore Formation by Amyloid-like Peptides: Effects of the Nonpolar–Polar Sequence Pattern

Rangubpit, W.; Sungted, S.; Wong-Ekkabut, J.; Distaffen, H.E.; Nilsson, B.L.; Dias, C.L.

ACS Chem. Neurosci., 2024, 15(18), 3354-3362, DOI: 10.1021/acschemneuro.4c00333

Hybrid Amyloid Quantum Dot Nano-Bio Assemblies to Probe Neuroinflammatory Damage

Chiang, W.; Urban, J.M.; Yanchik-Slade, F.E.; Stout, A.;  Hammond, J.M.;  Nilsson, B.L.; Gelbard, H.A.; Krauss, T.D.

ACS Chem. Neurosci. 2024, 15(17), 3124-3135 DOI: 10.1021/acschemneuro.4c00183

Peptide Self-Assembly into Amyloid Fibrils: Unbiased All-Atom Simulations

Nilsson, B.L.; Torabfam, G.C.; Dias C.L.

J. Phys. Chem. B., 2024, 128(14) 3320-3328 DOI:

10.1021/acs.jpcb.3c07861

Impact of peptide sequence on functional siRNA delivery and gene knockdown with cyclic amphipathic peptide delivery agents

Jagrosse, M.L.; Baliga, U.K.; Jones, C.W.; Russell, J.J.; García, C.I.; Najar, R.A.; Rahman, A.; Dean, D.A.; Nilsson, B.L.

Mol. Pharm. 2023, 20(12), 6090-6103 DOI: 10.1021/acs.molpharmaceut.3c00455

Chirality in Peptide Self-Assembly and Aggregation

Yanchik-Slade, F.E.; von Hofe, J. E.; Nilsson, B.L.

Peptide Bionanomaterials: From Design to Application, Springer International Publishing, 2023, 229-253

β-Sheet and β-Hairpin Peptide Nanomaterials

Quigley, E.; Nilsson, B.L.

Peptide Bionanomaterials: From Design to Application, Springer International Publishing, 2023, 53-86

Quantum Dot Biomimetic for SARS-CoV-2 to Interrogate Blood–Brain Barrier Damage Relevant to NeuroCOVID Brain Inflammation

Chiang, W.; Stout, A.; Yanchik-Slade, F.; Li, H.; Terrando, N.; Nilsson, B.L; Gelbard, H.A.; Krauss, T.D.

ACS Appl. Nano Mater., 2023, 6(16), 15094-15107 DOI: 10.1021/acsanm.3c02719

Supramolecular phenylalanine-derived hydrogels for the sustained release of functional proteins

Jagrosse, M.L.; Agredo, P.; Abraham, B.L.; Toriki, E.S.;  Nilsson, B.L.

ACS Biomater. Sci. Eng., 2023, 9(2), 784-796 DOI: 10.1021/acsbiomaterials.2c01299

Anion Effects on the Supramolecular Self-Assembly of Cationic Phenylalanine Derivatives

Abraham, B.L.; Agredo, P.; Mensah, S.G.; Nilsson, B.L.

Langmuir, 2022, 38 (50), 15494-15505 DOI: 10.1021/acs.langmuir.2c01394

Using all-atom simulations in explicit solvent to study aggregation of amphipathic peptides into amyloid-like fibrils

Jalali, S.; Yang, Y.; Mahmoudinobar, F.; Singh, S.M.;  Nilsson, B.L.; Dias, C.

J. Mol. Liq., 2022, 347, 118283

Side-chain halogen effects on self-assembly and hydrogenation of cationic phenylalanine derivatives

Abraham, B.L.; Mensah, S.G.; Gwinnwell, B.R.; Nilsson, B.L.

J. Soft Matter, 2022, 18 (22), 5999-6008 DOI: 10.1039/D2SM00713D

Peptide Cross-β Nanoarchitectures: Characterizing Self-Assembly Mechanisms, Structure, and Physicochemical Properties

Jones, C.W,; Distaffen, H. E.; Nilsson, B.L.

Molecular Architectonics and Nanoarchitectonics, 2022, 179-207 DOI: 10.1007/978-981-16-4189-3_8

Capacity for increased surface area in the hydrophobic core of beta-sheet peptide bilayer nanoribbons

Jones, C. W.; Morales, C. G.; Eltiste, S. L.; Yanchik-Slade, F. E.; Lee, N. R.; Nilsson, B. L.

J. Pept. Sci. 2021, 27, e3334. DOI: 10.1002/psc.3334

Binding Mechanisms of Amyloid-like Peptides to Lipid Bilayers and Effects of Divalent Cations

Yang, Y.; Jalali, S.; Nilsson, B. L.; Dias, C. L.

ACS Chem. Neurosci. 2021, 12, 2027-2035. DOI: 10.1021/acschemneuro.1c00140

Defining the Landscape of the Pauling-Corey Rippled Sheet: An Orphaned Motif Finding New Homes

Raskatov, J. A.; Schneider, J. P.; Nilsson, B. L.

Acc. Chem. Res. 2021, 54, 2488-2501. DOI: 10.1021/acs.accounts.1c00084

Multivalent display of chemical signals on self-assembled peptide scaffolds

Distaffen, H. E.; Jones, C. W.; Abraham, B. L.; Nilsson, B. L.

Pept. Sci. 2021, 113, e24224. DOI: 10.1002/pep2.24224

Quantum Dots for Improved Single-Molecule Localization Microscopy

Urban, J. M.; Chiang, W.; Hammond, J. W.; Cogan, N. M. B.; Litzburg, A.; Burke, R.; Stern, H. A.; Gelbard, H. A.; Nilsson, B. L.; Krauss, T. D.

J. Phys. Chem. B 2021, 125, 2566-2576. DOI: 10.1021/acs.jpcb.0c11545

Effects of Ions and Small Compounds on the Structure of Aβ42 Monomers

Mahmoudinobar, F.; Nilsson, B. L.; Dias, C. L.

J. Phys. Chem. B 2021, 125, 1085-1097. DOI: 10.1021/acs.jpcb.0c09617

Impact of gelation method on thixotropic properties of phenylalanine-derived supramolecular hydrogels

Quigley, E.; Johnson, J.; Liyanage, W.; Nilsson, B. L.

Soft Matter 2020, 16, 10158-10168. DOI: 10.1039/D0SM01217C

Electrostatic interactions regulate the release of small molecules from supramolecular hydrogels

Abraham, B. L.; Toriki, E. S.; Tucker, N. J.; Nilsson, B. L.

J. Mater. Chem B 2020, 8, 6366-6377. DOI: 10.1039/D0TB01157F

Strategy to Identify Improved N-Terminal Modifications for Supramolecular Phenylalanine-Derived Hydrogelators

Abraham, B. L.; Liyanage, W.; Nilsson, B. L.

Langmuir 2019, 35, 14939-14948. DOI: 10.1021/acs.langmuir.9b02971

RNAi therapeutic strategies for acuterespiratory distress syndrome

Jagrosse, M. L.; Dean, D. A.; Rahman, A.; Nilsson, B. L.

Translational Research 2019, 214, 30-49. DOI: 10.1016/j.trsl.2019.07.011

Rippled β-Sheet Formation by an Amyloid-β Fragment Indicates Expanded Scope of Sequence Space for Enantiomeric β-Sheet Peptide Coassembly

Urban, J. M.; Ho, J.; Piester, G.; Fu, R.; Nilsson, B. L.

Molecules 2019, 24, 1983. DOI: 10.3390/molecules24101983

Thermodynamic Stability of Polar and Nonpolar Amyloid Fibrils

Mahmoudinobar, F.; Urban, J. M.; Su, Z.; Nilsson, B. L.; Dias, C. L.

J. Chem. Theory Comput. 2019, 15, In Press. DOI: 10.1021/acs.jctc.9b00145

Low-Molecular-Weight Supramolecular Hydrogels for Sustained and Localized in Vivo Drug Delivery

Raymond, D. M.; Abraham, B. L.; Fujita, T.; Watrous, M. J.; Toriki, E. S.; Takano, T.; Nilsson, B. L.

ACS Appl. Bio Mater. 2019, 2, 2116-2124. DOI: 10.1021/acsabm.9b00125

Multicomponent peptide assemblies

Raymond, D. M.; Nilsson, B. L.

Chem. Soc. Rev. 2018, 47, 3659-3720. DOI: 10.1039/C8CS00115D

Comparison of the Self-Assembly Behavior of Fmoc-Phenylalanine and Corresponding Peptoid Derivatives

Rajbhandary, A.; Brennessel, W. W.; Nilsson, B. L.

Cryst. Growth. Des. 2018, 18(2), 623-632. DOI: 10.1021/acs.cgd.7b00709

Balancing Hydrophobicity and Sequence Pattern to Influence Self-Assembly of Amphipathic Peptides

Betush, R. J.; Urban, J.; Nilsson, B. L.

Biopolymers 2018, 110, e23099. DOI: 10.1002/bip.23099

Redox-Sensitive Reversible Self-Assembly of Amino Acid-Naphthalene Diimide Conjugates

Liyanage, W.; Rubeo, P. W.

Interface Focus 2017, 7, 20160099. DOI: 10.1098/rsfs.2016.0099

Modulating Supramolecular Peptide Hydrogel Viscoelasticity Using Biomolecular Recognition

DiMaio, J. T. M.; Doran, T. M.; Ryan, D. M.; Raymond, D. M.; Nilsson, B. L.

Biomacromolecules 2017, 18, 3591-3599. DOI: 10.1021/acs.biomac.7b00925

Display of Functional Proteins on Supramolecular Peptide Nanofibrils Using a Split-Protein Strategy

DiMaio, J. T. M.; Raymond, D. M.; Nilsson, B. L.

Org. Biomol. Chem. 2017, 15, 5279-5283. DOI: 10.1039/C7OB01057E

Self-Assembly, Hydrogelation, and Nanotube Formation by Cation-Modified Phenylalanine Derivatives

Rajbhandary, A.; Raymond, D. M.; Nilsson, B. L.

Langmuir 2017, 33, 5803-5813. DOI: 10.1021/acs.langmuir.7b00686

Investigating the Effects of Peptoid Substitutions in Self-Assembly of Fmoc-Diphenylalanine Derivatives

Rajbhandary, A.; Nilsson, B. L.

Biopolymers 2017, 108, e22994. DOI: 10.1002/bip.22994

Amyloid-Inspired Optical Waveguides from Multicomponent Crystalline Microtubes

Liyanage, W.; Cogan, N. M. B.; Nilsson, B. L.

ChemNanoMat 2016, 2, 800-804. DOI: 10.1002/cnma.201600123

Functional Delivery of siRNA by Disulfide-Constrained Cyclic Amphipathic Peptides

Welch, J. J.; Swanekamp, R. J.; King, C.; Dean, D. A.; Nilsson, B. L.

ACS Med. Chem. Lett. 2016, 7, 584-589. DOI: 10.1021/acsmedchemlett.6b00031

Substituent Effects on the Self-Assembly/Coassembly and Hydrogelation of Phenylalanine Derivatives

Liyanage, W.; Nilsson, B. L.

Langmuir 2016, 32, 787-799. DOI: 10.1021/acs.langmuir.5b03227

Mechanisms of Tau and Aβ-induced Excitotoxicity

Pallo, S. P.; DiMaio, J.; Cook, A.; Nilsson, B.; Johnson, G. V. W.

Brain Res. 2016, 1634, 119-131. DOI: 10.1016/j.brainres.2015.12.048

Spontaneous Transition of Self-Assembled Hydrogel Fibrils into Crystalline Microtubes Enables a Rational Strategy to Stabilize the Hydrogel State

Liyanage, W.; Brennessel, W. W.; Nilsson, B. L.

Langmuir 2015, 31, 9933-9942. DOI: 10.1021/acs.langmuir.5b01953

Multicomponent Dipeptide Hydrogels as Extracellular Matrix-Mimetic Scaffolds for Cell Culture Applications

Liyanage, W.; Vats, K.; Rajbhandary, A.; Benoit, D. S. W.; Nilsson, B. L.

Chem. Commun. 2015, 51, 11260-11263. DOI: 10.1039/C5CC03162A

Proteolytic Stability of Amphipathic Peptide Hydrogels Composed of Self-Assembled Pleated β-Sheet or Coassembled Rippled β-Sheet Fibrils

Swanekamp, R. J.; Welch, J. J.; Nilsson, B. L.

Chem. Commun. 2014, 50, 10133-10136. DOI: 10.1039/C4CC04644G

Selective Suspension of Single-Walled Carbon Nanotubes Using β-Sheet Polypeptides

Cogan, N. M. B.; Bowerman, C. J.; Nogai, L. J.; Nilsson, B. L.; Krauss, T. D.

J. Phys. Chem. C 2014, 118, In press. DOI: 10.1021/jp410870y

Reversible Photocontrol of Self-Assembled Peptide Hydrogel Viscoelasticity

Doran, T. M.; Ryan, D. M.; Nilsson, B. L.

Polym. Chem. 2014, 5, 241-248. DOI: 10.1039/C3PY00903C

Sequence Length Determinants for Self-Assembly of Amphipathic β-Sheet Peptides

Lee, N. R.; Bowerman, C. J.; Nilsson, B. L.

Biopolymers 2013, 100, 738-750. DOI: 10.1002/bip.22248

Fluorescence Detection of Cationic Amyloid Fibrils in Human Semen

Easterhoff, D.; DiMaio, J. T. M.; Liyanage, W.; Lo, C.-W.; Bae, W.; Doran, T. M.; Smrcka, A.; Nilsson, B. L.; Dewhurst, S.

Bioorg. Med. Chem. Lett. 2013, 23, 5199-5202. DOI: 10.1016/j.bmcl.2013.06.097

Effects of Varied Sequence Pattern on the Self-Assembly of Amphipathic Peptides

Lee, N. R.; Bowerman, C. J.; Nilsson, B. L.

Biomacromolecules 2013, 14, 3267-3277. DOI: 10.1021/bm400876s

Self-Assembly of Amphipathic β-Sheet Peptides: Insights and Applications

Bowerman, C. J.; Nilsson, B. L.

Biopolymers 2012, 98, 169-184. DOI: 10.1002/bip.22058

Coassembly of Enantiomeric Amphipathic Peptides into Amyloid-Inspired Rippled β-Sheet Fibrils

Swanekamp, R. J.; DiMaio, J. T. M.; Bowerman, C. J.; Nilsson, B. L.

J. Am. Chem. Soc. 2012, 134, 5556-5559. DOI: 10.1021/ja301642c

Seminal Plasma Accelerates Semen-derived Enhancer of Viral Infection (SEVI) Fibril Formation by the Prostatic Acid Phosphatase (PAP[248-286]) Peptide

Olsen, J. S.; DiMaio, J. T. M.; Doran, T. M.; Brown, C.; Nilsson, B. L.; Dewhurst, S.

J. Biol. Chem. 2012, 287, 11842-11849. DOI: 10.1074/jbc.M111.314336

Turn Nucleation Perturbs Amyloid-β Self-Assembly and Cytotoxicity

Doran, T. M.; Anderson, E. A.; Latchney, S. E.; Opanashuk, L. A.; Nilsson, B. L.

J. Mol. Biol. 2012, 421, 315-328. DOI: 10.1016/j.jmb.2012.01.055

An Azobenzene Photoswitch Sheds Light on Turn Nucleation in Amyloid-β Self-Assembly

Doran, Todd M; Anderson, E. A.; Latchney, S. E.; Opanashuk, L. A.; Nilsson, B. L.

ACS Chem. Neurosci. 2012, 3, 211-220. DOI: 10.1021/cn2001188

Role of Amino Acid Hydrophobicity, Aromaticity and Molecular Volume on IAPP(20-29) Amyloid Self-Assembly

Doran, Todd M.; Kamens, Alissa J.; Byrnes, Nadia K.; Nilsson, Bradley L.

Proteins 2012, 80, 1053-1065. DOI: 10.1002/prot.24007

Self-Assembled Amino Acids and Dipeptides as Noncovalent Hydrogels for Tissue Engineering

Ryan, Derek M.; Nilsson, Bradley L.

Polym. Chem. 2012, 3, 18-33. DOI: 10.1039/C1PY00335F

Complementary π–π Interactions Induce Multi-Component Coassembly into Functional Fibrils

Ryan, Derek M.; Doran, Todd M.; Nilsson, Bradley L.

Langmuir 2011, 27, 11145-11156. DOI: 10.1021/la202070d

Tuning β-Sheet Peptide Self-Assembly and Hydrogelation Behavior by Modification of Sequence Hydrophobicity and Aromaticity

Bowerman, Charles J.; Liyanage, Wathsala, Federation, Alexander J.; Nilsson, Bradley L.

Biomacromolecules 2011, 12, 2735-2745. DOI: 10.1021/bm200510k

Effect of C-Terminal Modification on the Self-Assembly and Hydrogelation of Fluorinated Fmoc-Phe

Ryan, Derek M.; Doran, Todd M.; Anderson, Samuel B.; Nilsson, Bradley L.

Langmuir 2011, 27, 4029-4039. DOI: 10.1021/la1048375

Enhancement of HIV-1 Infectivity by Simple, Self-Assembling Modular Peptides

Easterhoff, David; DiMaio, John T. M.; Doran, Todd M.; Dewhurst, Stephen; Nilsson, Bradley L.

Biophys. J. 2011, 100, 1325-1334. DOI: 10.1016/j.bpj.2011.01.037

Clarifying the Influence of Core Amino Acid Hydrophobicity, Secondary Structure Propensity, and Molecular Volume on Amyloid-β 16-22 Self-Assembly

Senguen, F. Timur; Doran, Todd M.; Anderson, Elizabeth A.; Nilsson, Bradley L.

Mol. BioSyst. 2011, 7, 497-510. DOI: 10.1039/C0MB00210K

Probing Aromatic, Hydrophobic, and Steric Effects on the Self-Assembly of an Amyloid-β Fragment Peptide

Senguen, F. Timur; Lee, Naomi, R.; Gu, Xianfeng; Ryan, Derek M.; Doran, Todd M.; Anderson, Elizabeth A.; Nilsson, Bradley L.

Mol. BioSyst. 2011, 7, 486-496. DOI: 10.1039/C0MB00080A

Stabilizing Self-Assembled Fmoc-F5-Phe Hydrogels by Co-Assembly with PEG-Functionalized Monomers

Ryan, Derek M.; Doran, Todd M.; Nilsson, Bradley L.

Chem. Commun. 2011, 47, 475-477. DOI: 10.1039/C0CC02217A

Amyloid Binding Small Molecules Efficiently Block SEVI and Semen-Mediated Enhancement of HIV-1 Infection

Olsen, Joanna S.; Brown, Caitlin; Capule, Christina C.; Rubinshtein, Mark; Doran, Todd M.; Srivastava, Rajesh K.; Feng, Chanyong; Nilsson, Bradley L.; Yang, Jerry; Dewhurst, Stephen

J. Biol. Chem. 2010, 285, 35488-35496. DOI: 10.1074/jbc.M110.163659

The Influence of Side-Chain Halogenation on the Self-Assembly and Hydrogelation of Fmoc-Phenylalanine Derivatives

Ryan, Derek M.; Anderson, Samuel B.; Nilsson, Bradley L.

Soft Matter 2010, 6, 3220-3231. DOI: 10.1039/c0sm00018c

A Reductive Trigger for Peptide Self-Assembly and Hydrogelation

Bowerman, Charles, J.; Nilsson, Bradley L.

J. Am. Chem. Soc. 2010, 132, 9526-9527. DOI: 10.1021/ja1025535

Self-Assembly and Hydrogelation Promoted by F5-Phenylalanine

Ryan, Derek M.; Anderson, Samuel B.; Senguen, F. Timur; Youngman, Randall E.; Nilsson, Bradley L.

Soft Matter 2010, 6, 475-479. DOI: 10.1039/b916738b

The Effect of Increasing Hydrophobicity on the Self-Assembly of Amphipathic β-Sheet Peptides

Bowerman, Charles J.; Ryan, Derek M.; Nissan, David A.; Nilsson, Bradley L.

Mol. BioSyst. 2009, 5, 1058-1069. DOI: 10.1039/b904439f