2003-present
Alkynyl Halo-Aza-Prins Annulative Couplings
Jackson J. Hernandez, Alexandra P. Lawrie, Alison J. Frontier, J. Org. Chem. 2023, 88, 16065 – 16075
Nitrogen-interrupted Halo-Prins/Halo-Nazarov Fragment Coupling Cascade for the Synthesis of Indolines
Aleksa Milosavljevic, Connor Holt, Alison J. Frontier, Chem. Sci. 2023, 14, 5431 – 5437
Alkynyl Prins Carbocyclization Cascades for the Synthesis of Linear-Fused Heterocyclic Ring Systems
Jackson J. Hernandez, Alison J. Frontier, Chem. Sci. 2022, 13, 13836 – 13842
Approach to High-Nitrogen Materials with Dual-Use Properties via Tetraaza-Nazarov Cyclization
Divergent Reactivity of Triaryldivinyl Ketones: Competing 4π and Putative 6π Electrocyclization Pathways
Anton V. Yadykov, Artem E. Eremchenko, Aleksa Milosavljevic, Alison J. Frontier, Valerii Z. Shirinian, J. Org. Chem. 2022, 87, 13643 − 13652
Merging Strategy, Improvisation, and Conversation to Solve Problems in Target Synthesis
Alison J. Frontier, Paul P. Sinclair, Acc. Chem. Res. 2021, 54, 1817 – 1829
Synthesis of Spirocyclic Isoindolones Using an Alkynyl aza-Prins/Oxidative halo-Nazarov Cyclization Sequence
Jackson J. Hernandez, Alison J. Frontier, Org. Lett. 2021, 23, 1782 – 1786
New Twists in Nazarov Cyclization Chemistry
Alison J. Frontier, Jackson J. Hernandez, Acc. Chem. Res. 2020, 53, 1822 - 1832
One-Pot Double-Annulation Strategy for the Synthesis of Unusual Fused Bis-Heterocycles
Shukree Abdul-Rashed, Georgios Alachouzos, William W. Brennessel, Alison J. Frontier; Org. Lett. 2020, 22, 4350–4354
Stereochemical Relay through a Cationic Intermediate: Helical Preorganization Dictates Direction of Conrotation in the halo-Nazarov Cyclization
Georgios Alachouzos, Connor Holt, Alison J. Frontier; Org. Lett. 2020, 22, 4010–4015
Alkynyl Prins and Alkynyl Aza-Prins Annulations: Scope and Synthetic Applications
Shukree Abdul-Rashed, Connor Holt, Alison J. Frontier; Synthesis 2020, 52, 1991-2007
Tuning Mechanism through Buffer Dependence of Hydrogen Evolution Catalyzed by a Cobalt Mini-enzyme
Jennifer M. Le, Georgios Alachouzos, Marco Chino, Alison J. Frontier, Angela Lombardi, Kara L. Bren; Biochemistry 2020, 59, 1289–1297
Leveraging the Halo-Nazarov Cyclization for the Chemodivergent Assembly of Functionalized Haloindenes and Indanones
Connor Holt, Georgios Alachouzos, Alison J. Frontier; J. Am. Chem. Soc. 2019, 141, 5461-5469
Cationic Cascade for Building Complex Polycyclic Molecules from Simple Precursors: Diastereoselective Installation of Three Contiguous Stereogenic Centers in a One-Pot Process
Georgios Alachouzos, Alison J. Frontier; J. Am. Chem. Soc. 2019, 141, 118-122
Noncanonical Cation−π Cyclizations of Alkylidene β-Ketoesters: Synthesis of Spiro-fused and Bridged Bicyclic RingSystems
Dylan E. Parsons, Alison J. Frontier; Org. Lett. 2019, 21, 2008–2012
Toward the Asymmetric Synthesis of Tetrapetalone A: Preparation of an Enantioenriched Indane Intermediate and Strategy for Endgame Glycosylation Strategy
Peter N. Carlsen, Eric G. Stoutenburg, Alison J. Frontier; Synthesis, 2018,50, 1238-1245
Diastereoselective Construction of Densely Functionalized 1-Halocyclopentenes Using an Alkynyl Halo-Prins/Halo-Nazarov Cyclization Strategy
Georgios Alachouzos and Alison J. Frontier; Angew.Chem.Int.Ed.2017,56, 15030–15034
Nazarov Cyclization/Internal Redox Cyclization Sequence for the Synthesis of N-Heterocyclic Bridged Ring Systems
Huang, Yu-Wen, Frontier, Alison J. Org. Lett. 2016, 18, 4896-4899.
Studies toward the AB ring system of the tetrapetalone natural products
Carlsen, P. N.; Jiang, C.; Herrick, I. R.; Frontier, A. J. Tetrahedron, 2015, 71, 5886–5896 (Invited paper for special issue honoring Barry Trost)
Enantioselective Nazarov cyclization catalyzed by a Cinchona alkaloid derivative
Huang, Yu-Wen; Frontier, A. J. Tetrahedron Lett. 2015, 56, 3523-3526 (Invited paper for special issue honoring Harry Wasserman)
No Acid Required: 4p and 6p Electrocyclization Reactions of Dienyl Diketones for the Synthesis of Cyclopentenones and 2H-Pyrans
Jacob, Steven; Brooks, Joshua L.; Frontier, A. J. J. Org. Chem. 2014, 79, 10296–10302.
Synthesis of (±)-Tetrapetalone A-Me Aglycon
Carlsen, P. N.; Mann, T. J.; Hoveyda, A. H.; Frontier, A. J. Angew Chem. Int. Ed. 2014, 53, 9334-9338
Flavaglines Target Primitive Leukemia Cells and Enhance Anti-Leukemia Drug Activity
Callahan, K.; Minhajuddin, M.; Corbett, C.; Lagadinou, E.; Rossi, R.; Balys, M.; Pan, L.; Jacob, S.; Frontier, A.; Grever, M.; Lucas, D.; Kinghorn, A. D.; Liesveld, J. L.; Becker, M.; Jordan, C. Leukemia, 2014, 28, 1960–1968
The Phomactin Natural Products: From Isolation to Total Synthesis
Ciesielski, J.; Frontier, A. J. J. Org. Prep. Proc. Int., 2014, 46, 214-251
Preparation of 5-Hydroxycyclopentenones via Conjugate Addition-Initiated Nazarov Cyclization
Brooks, J. L.; Huang, Y.-W.; Frontier, A. J. Org. Syn., 2014, 91, 93.
Cationic Cyclizations and Rearrangements Promoted by a Heterogeneous Gold Catalyst
Vaidya, T.; Cheng, R.; Carlsen, P. N.; Frontier, A. J.; Eisenberg, R. Org. Lett., 2014, 16 (3), 800–803
Gold(I)-Catalyzed Iodination of Arenes
Lebœuf, D.; Ciesielski, J.; Frontier, A. J. Synlett, 2014, 25, 399-402.
Gold(III) Chloride-Catalyzed 6-endo-trig Oxa-Michael Addition Reactions for Diastereoselective Synthesis of Fused Tetrahydropyranones
Ciesielski, J.; Lebœuf, D.; Stern, H. A.; Frontier, A. J. Adv. Synth. Catal., 2013, 355, 2077-2082.
Cascade Cyclizations of Acyclic and Macrocyclic Alkynones: Studies toward the Synthesis of Phomactin A
Ciesielski, J.; Gandon, V.; Frontier, A. J. J. Org. Chem., 2013, 78, 9541-9552. (Featured Article)
Beyond the Divinyl Ketone: Innovations in the Generation and Nazarov Cyclization of Pentadienyl Cation Intermediates
Spencer, W. T. III; Vaidya, T.; Frontier, A. J. Eur. J. Org. Chem., 2013, 18, 3621-3633. Invited Microreview. Top 10 most accessed articles for May 2013
Efficient Nazarov Cyclization/Wagner-Meerwein Rearrangement Terminated by a Cu(II)-Promoted Oxidation: Synthesis of 4-Alkylidene Cyclopentenones
Lebœuf, D.; Theiste, E.; Gandon, V.; Daifuku, S. L.; Neidig, M. L.; Frontier, A. J. Chem. Eur. J., 2013, 19, 4842–4848.
Reagent Control of 1,2-Wagner-Meerwein Shift Chemoselectivity following Nazarov Cyclization: Application to the Total Synthesis of Enokipodin B
Lebœuf, D.; Wright, C. M.; Frontier, A. J. Chem. Eur. J., 2013, 19, 4835–4841.
Cyclization Cascades Initiated by 1,6-Conjugate Addition
Brooks, J. L.; Frontier, A. J. J. Am. Chem. Soc., 2012, 134, 16551-16553.
A Cycloaromatization Protocol for Synthesis of Polysubstituted Phenol Derivatives: Method Development and Mechanistic Studies
Spencer, W. T. III; Frontier, A. J. J. Org. Chem., 2012, 77, 7730–7736.
A Macrocyclic β-Iodoallenolate Intermediate is Key: Synthesis of the ABD Core of Phomactin A
Ciesielski, J.; Cariou, K.; Frontier, A. J. Org. Lett., 2012, 14, 4082-4085.
Experimental and Theoretical Studies on the Nazarov Cyclization/Wagner-Meerwein Rearrangement Sequence
Lebœuf, D.; Ciesielski, J.; Gandon, V.; Frontier, A. J. J. Am. Chem. Soc., 2012, 134, 6296–6308.
Total Synthesis of (±)-Rocaglamide via Oxidation-Initiated Nazarov Cyclization
Malona, J. A.; Cariou, K.; Spencer, W. T. III, Frontier, A. J. J. Org. Chem., 2012, 77, 1891–1908.
Using Nazarov Electrocyclization to Stage Chemoselective [1,2]-Migrations: Stereoselective Synthesis of Functionalized Cyclopentenones
Lebœuf, D.; Huang, J.; Gandon, V.; Frontier, A. J. Angew. Chem., Int. Ed., 2011, 50, 10981-10985.
Conjugate Addition-Initiated Nazarov Cyclization
Brooks, J. L.; Caruana, P. A.; Frontier, A. J. J. Am. Chem. Soc., 2011, 133, 12454-12457.
Catalytic Nazarov Cyclization: The State of the Art
Vaidya, T.; Frontier, A. J.; Eisenberg, R. ChemCatChem, 2011, 3, 1531-1548.
Understanding the fate of the oxyallyl cation following Nazarov electrocyclization: sequential Wagner-Meerwein migrations and the synthesis of spirocyclic cyclopentenones
Huang, J.; Lebœuf, D.; Frontier, A. J. J. Am. Chem. Soc., 2011, 133, 6307-6317.
Divergent Reaction Pathways of a Cationic Intermediate: Rearrangement and Cyclization of 2-Substituted Furyl and Benzofuryl Enones Catalyzed by Iridium(III)
Vaidya, T.; Manbeck, G.; Chen, S.; Frontier, A. J.; Eisenberg, R. J. Am. Chem. Soc., 2011, 113, 3300-3303.
Oxidation-Initiated Nazarov Cyclization of Vinyl Alkoxyallenes
Spencer, W. T. III; Levin, M. D.; Frontier, A. J. Org. Lett., 2011, 13, 414-417
Dicationic Palladium(II) Complexes as Active Lewis Acid Catalysts for Polarized Nazarov Cyclization
Zhang, J.; Vaidya, T.; Brennessel, W. W.; Frontier, A. J.; Eisenberg R. Organometallics, 2010, 29, 3341-3349.
Synthesis, Characterization, and Catalytic Properties of New Electrophilic Iridium(III) Complexes Containing the (R)-(+)-2,2′-Bis(diphenylphosphino)-1,1′-binaphthyl Ligand
Atesin, A. C.; Zhang, J.; Vaidya, T.; Brennessel, W. W.; Frontier, A. J.; Eisenberg, R. Inorg. Chem., 2010, 49, 4331- 4342.
A Highly Reactive Dicationic Iridium (III) Catalyst for the Polarized Nazarov Cyclization Reaction
Vaidya, T.; Atesin, A. C.; Herrick, I. R.; Frontier, A. J.; Eisenberg, R. Angew. Chem., Int. Ed., 2010, 49, 3363-3366.
β-Iodoallenolates as Springboards for Annulation Reactions
Ciesielski, J.; Canterbury, D. P.; Frontier, A. J. Org. Lett., 2009, 11, 4374-4377.
Nazarov Cyclization Initiated by Peracid Oxidation: The Total Synthesis of (±)-Rocaglamide
Malona, J. A.; Cariou, K.; Frontier, A. J. J. Am. Chem. Soc., 2009, 131, 7560–7561.
Formal Synthesis of Roseophilin
Bitar, A. Y., Frontier, A. J. Org. Lett., 2009, 11, 49-52.
A Torquoselective Extrusion of Isoxazoline N-Oxides. Application to the synthesis of Aryl Vinyl and Divinyl Ketones for Nazarov Cyclization
Canterbury, D. P.; Um, J.; Houk, K. N.; Frontier, A. J. Tetrahedron, 2009, 65, 3165-3179. Invited article for Tetrahedron Symposium-In-Print; honoring [award winner] Justin DuBois.
Origins of Stereoselectivity in the Oxido-Alkylidenation of Alkynes
Canterbury, D. P.; Frontier, A. J.; Um, J., Cheong, P.; Goldfeld, D.; Huhn, R.; Houk, K. N. Org. Lett.2008, 10, 4597-4600.
Polarizing the Nazarov Cyclization: The Impact of Dienone Substitution Pattern on Reactivity and Selectivity
He, W.; Meracz, I. R.; Atesin, T. A.; Caruana, P. A.; Kellenberger, C. A.; Frontier, A. J. J. Am. Chem. Soc.2008, 130, 1003-1011.
Total Synthesis of (+)-Merrilactone A
He, W.; Huang, J.; Sun, X.; Frontier, A. J. J. Am. Chem. Soc.,2008, 130, 300-308.
Stereoselective Synthesis of Pyrrolidine Derivatives via Reduction of Substituted Pyrroles
Jiang, C.; Frontier, A. J. Org. Lett., 2007, 9, 4939-4942.
Palladium(II)- and Mercury(II)-Catalyzed Rearrangements of Propargyl Acetates
Caruana, P. A.; Frontier. A. J. Tetrahedron, 2007, 63, 10646-10656.
Development of a Nazarov Cyclization/ Wagner-Meerwein Rearrangement Sequence for the Stereoselective Synthesis of Spirocycles
Huang, J.; Frontier, A. J. J. Am. Chem. Soc., 2007, 129, 8060-8061.
Total Synthesis of (+)-Merrilactone A via Catalytic Nazarov Cyclization
He, W.; Huang, J.; Sun, X.; Frontier, A. J. J. Am. Chem. Soc., 2007, 129, 498-499.
A General Method for the Catalytic Nazarov Cyclization of Heteroaromatic Compounds
Malona, J. A.; Colbourne, J. M.; Frontier, A. J. Org. Lett., 2006, 8, 5661-5664.
Tandem Nazarov Cyclization-Michael Addition Sequence Catalyzed by an Ir(III) Complex
Janka, M..; He, W.; Haedicke, I. E.; Fronczek, F. R.; Frontier, A. J.; Eisenberg, R. J. Am. Chem. Soc., 2006, 128, 5312-5313.
The Nazarov Cyclization in Organic Synthesis. Recent Advances
Frontier, A. J.; Collison, C. Tetrahedron2005, 61, 7577-7606. Invited Tetrahedron Report (review). This review was one of the top 25 most downloaded papers in Tetrahedron in 2006, and one of the top 50 between 2004-2007.
Preorganization in the Nazarov Cyclization: The Role of Adjacent Coordination Sites in the Highly Lewis Acidic Catalyst [IrMe(CO)(dppe)(DIB)](BAr4f)2
Janka, M.; He, W.; Frontier, A. J.; Flaschenriem, C.; Eisenberg, R. Tetrahedron2005, 61, 6193-6206. Invited paper for Tetrahedron Symposium-In-Print; Catalysis in Industry and Academia.
Dearomatization of Furans via [2,3] - Still Wittig Rearrangement
Caruana, P. A.; Frontier. A. J. Tetrahedron, 2004, 60, 10921-10926.
Efficient Catalysis of Nazarov Cyclization Using a Cationic Iridium Complex Possessing Adjacent Labile Coordination Sites
Janka, M.; He, W.; Frontier, A. J.; Eisenberg, R. J. Am. Chem. Soc., 2004, 126, 6864-6865.
Polarizing the Nazarov Cyclization: Efficient Catalysis under Mild Conditions
He, W.; Sun, X.; Frontier, A. J. J. Am. Chem. Soc., 2003, 125, 14278-14279; addition/ correctionJ. Am. Chem. Soc., 2004, 126, 10493-10493.