{"id":526,"date":"2025-09-27T19:06:58","date_gmt":"2025-09-27T23:06:58","guid":{"rendered":"https:\/\/sas.rochester.edu\/chm\/groups\/paton\/?page_id=526"},"modified":"2025-10-07T10:16:39","modified_gmt":"2025-10-07T14:16:39","slug":"publications-2","status":"publish","type":"page","link":"https:\/\/sas.rochester.edu\/chm\/groups\/paton\/publications-2\/","title":{"rendered":"Publications"},"content":{"rendered":"

<\/p>\n

\n
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Mentored Publications<\/h1>\n

Postdoctoral Research (2021 \u2011 2025)<\/span><\/h1>\n<\/header>\n
\n
\n

\"\"<\/h3>\n

Generation of connections between protein sequence space and chemical space to enable a predictive model for biocatalysis<\/h3>\n

Authors:<\/strong> Alexandra E. Paton, Daniil A. Boiko, Jonathan C. Perkins, Nicholas I. Cemalovic, Thiago Resch\u00fctzegger, Gabe Gomes, Alison R. H. Narayan<\/p>\n

Nature, 2025, 646<\/b>, 108\u2013116.<\/a><\/p>\n

Nature Briefing<\/a><\/p>\n

 <\/p>\n

\"\"<\/h3>\n

Site\u2011 and stereoselective enzymatic halogenation of terpenoids by substrate anchoring and protein engineering<\/h3>\n

Authors:<\/strong> Colby S. Kayrouz, Jenna L. Manske, Mart\u00ed Gar\u00e7on, Isaac A. Joyner, Yuehan Wang, Yifei Ge, Alexandra E. Paton, Alison R. H. Narayan, John F. Hartwig<\/p>\n

J. Am. Chem. Soc., 2025, ASAP.\u00a0<\/a><\/p>\n

 <\/p>\n<\/article>\n

\n

\"Figure<\/h3>\n

Ancestral Sequence Reconstruction to Accelerate Non-heme Iron-dependent Biocatalyst Engineering<\/h3>\n

Authors:<\/strong> Jos\u00e9 R. Hern\u00e1ndez-Mel\u00e9ndez, Alexandra E. Paton, Jonathan C. Perkins, Di Yang, Chang-Hwa Chiang, Alison R. H. Narayan<\/p>\n

ACS Cent. Sci., 2025, ASAP<\/a><\/p>\n

 <\/p>\n<\/article>\n

\n

\"\"<\/h3>\n

Enzyme Library\u2011enabled Chemoenzymatic Tropolone Synthesis<\/h3>\n

Authors:<\/strong> J. C. Perkins*, A. E. Paton*, J. R. Hern\u00e1ndez\u2011Mel\u00e9ndez, A. T. Saucedo, J. S. Pyser, A. R. Narayan<\/p>\n

ChemRxiv, 2023<\/a><\/p>\n<\/article>\n<\/section>\n

<\/p>\n

\n
\n

Graduate Research (2017 \u2011 2021)<\/h2>\n
\n

\"\"<\/h3>\n

The synthesis and use of \u03b3\u2011chloro\u2011enamides for the subsequent construction of novel enamide\u2011containing small molecules<\/h3>\n

Authors:<\/strong> Alexandra E. Golliher, Antonio J. Tenorio, Brandon M. Cornali, Erika Y. Monroy, Rodolfo Tello\u2011Aburto, F. Omar Holguin, William A. Maio<\/p>\n

Tetrahedron, 2021, Vol. 102, p. 132536<\/a><\/p>\n

 <\/p>\n<\/article>\n

\n

\"\"<\/h3>\n

Using (+)\u2011carvone to access novel derivatives of (+)\u2011ent\u2011cannabidiol: The first asymmetric syntheses of (+)\u2011ent\u2011CBDP and (+)\u2011ent\u2011CBDV<\/h3>\n

Authors:<\/strong> Alexandra E. Golliher, Antonio J. Tenorio, Nina O. Dimauro, Nicolas R. Mairata, F. Omar Holguin, William Maio<\/p>\n

Tetrahedron Letters, 2021, Vol. 67, p. 152891<\/a><\/p>\n

 <\/p>\n<\/article>\n

\n

\"\"<\/h3>\n

Asymmetric Total Synthesis and Revision of Absolute Stereochemistry for (+)\u2011Taumycin A: An Approach that Exploits Orthogonally Protected Quasienantiomers<\/h3>\n

Authors:<\/strong> Uttar K. Shrestha, Alexandra E. Golliher, Tara D. Newar, F. Omar Holguin, William A. Maio<\/p>\n

J. Org. Chem. 2021, 86, 16, 11086\u201311099<\/a><\/p>\n

 <\/p>\n

\"\"Lewis\u2011Acid\u2011Mediated Union of Epoxy\u2011Carvone Diastereomers with Anisole Derivatives: Mechanistic Insight and Application to the Synthesis of Non\u2011natural CBD Analogues<\/span><\/p>\n<\/article>\n

Authors:<\/strong> Sophia J. Bailey, Rishi R. Sapkota, Alexandra E. Golliher, Barry Dungan, Marat Talipov, F. Omar Holguin, William A. Maio*<\/p>\n

Org. Lett. 2018, 20, 15, 4618\u20134621<\/a><\/p>\n

 <\/p>\n

\n

\"\"<\/h3>\n

Exploiting Carvone To Demonstrate Both Stereocontrol and Regiocontrol: 1,2\u2011 vs 1,4\u2011Addition of Grignard Reagents and Organocuprates<\/h3>\n

Authors:<\/strong> Thai Phat Truong, Sophia J. Bailey, Alexandra E. Golliher, Erika Y. Monroy, Uttar K. Shrestha, William A. Maio<\/p>\n

J. Chem. Educ. 2018, 95, 3, 438\u2013444<\/a><\/p>\n<\/article>\n<\/section>\n

<\/p>\n

\n
\n

Undergraduate Research (2013 \u2011 2017)<\/h2>\n
\n

\"\"<\/h3>\n

Proteopedia entry: G\u2011protein coupled receptors<\/h3>\n

 <\/p>\n

Authors:<\/strong> R. Jeremy Johnson, Jacob Applegarth, Steven Bennett, Sydney Caskey, Connor Coatney, Kurt Corsbie, Allison Cotter, Daniel Cotter, Alexis Coulis, Heather Hansen, Whitney Hart, Cutter Koehler, Andrew Koelper, Stephanie Kuhlman, Chandler Mitchell, Blake Moskal, Olivia Murfield, Allie Paton, Daniel Schemenauer, Brittany Stankavich, Clayton Taylor, Brent Waibel, L. Dean Williams<\/p>\n

Biochem. Mol. Biol. Educ., 2017, 45, 277\u2013278<\/a><\/p>\n<\/article>\n<\/section>\n<\/section>\n","protected":false},"excerpt":{"rendered":"

Mentored Publications Postdoctoral Research (2021 \u2011 2025) Generation of connections between protein sequence space and chemical space to enable a predictive model for biocatalysis Authors: Alexandra E. Paton, Daniil A.…<\/p>\n","protected":false},"author":86,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-526","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nPublications - Paton Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sas.rochester.edu\/chm\/groups\/paton\/publications-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications - Paton Lab\" \/>\n<meta property=\"og:description\" content=\"Mentored Publications Postdoctoral Research (2021 \u2011 2025) Generation of connections between protein sequence space and chemical space to enable a predictive model for biocatalysis Authors: Alexandra E. 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