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Publications

Mentored Publications

Postdoctoral Research (2021 ‑ 2025)

Generation of connections between protein sequence space and chemical space to enable a predictive model for biocatalysis

Authors: Alexandra E. Paton, Daniil A. Boiko, Jonathan C. Perkins, Nicholas I. Cemalovic, Thiago Reschützegger, Gabe Gomes, Alison R. H. Narayan

Nature, 2025, 646, 108–116.

Nature Briefing

 

Site‑ and stereoselective enzymatic halogenation of terpenoids by substrate anchoring and protein engineering

Authors: Colby S. Kayrouz, Jenna L. Manske, Martí Garçon, Isaac A. Joyner, Yuehan Wang, Yifei Ge, Alexandra E. Paton, Alison R. H. Narayan, John F. Hartwig

J. Am. Chem. Soc., 2025, ASAP. 

 

Figure 1

Ancestral Sequence Reconstruction to Accelerate Non-heme Iron-dependent Biocatalyst Engineering

Authors: José R. Hernández-Meléndez, Alexandra E. Paton, Jonathan C. Perkins, Di Yang, Chang-Hwa Chiang, Alison R. H. Narayan

ACS Cent. Sci., 2025, ASAP

 

Enzyme Library‑enabled Chemoenzymatic Tropolone Synthesis

Authors: J. C. Perkins*, A. E. Paton*, J. R. Hernández‑Meléndez, A. T. Saucedo, J. S. Pyser, A. R. Narayan

ChemRxiv, 2023


Graduate Research (2017 ‑ 2021)

The synthesis and use of γ‑chloro‑enamides for the subsequent construction of novel enamide‑containing small molecules

Authors: Alexandra E. Golliher, Antonio J. Tenorio, Brandon M. Cornali, Erika Y. Monroy, Rodolfo Tello‑Aburto, F. Omar Holguin, William A. Maio

Tetrahedron, 2021, Vol. 102, p. 132536

 

Using (+)‑carvone to access novel derivatives of (+)‑ent‑cannabidiol: The first asymmetric syntheses of (+)‑ent‑CBDP and (+)‑ent‑CBDV

Authors: Alexandra E. Golliher, Antonio J. Tenorio, Nina O. Dimauro, Nicolas R. Mairata, F. Omar Holguin, William Maio

Tetrahedron Letters, 2021, Vol. 67, p. 152891

 

Asymmetric Total Synthesis and Revision of Absolute Stereochemistry for (+)‑Taumycin A: An Approach that Exploits Orthogonally Protected Quasienantiomers

Authors: Uttar K. Shrestha, Alexandra E. Golliher, Tara D. Newar, F. Omar Holguin, William A. Maio

J. Org. Chem. 2021, 86, 16, 11086–11099

 

Lewis‑Acid‑Mediated Union of Epoxy‑Carvone Diastereomers with Anisole Derivatives: Mechanistic Insight and Application to the Synthesis of Non‑natural CBD Analogues

Authors: Sophia J. Bailey, Rishi R. Sapkota, Alexandra E. Golliher, Barry Dungan, Marat Talipov, F. Omar Holguin, William A. Maio*

Org. Lett. 2018, 20, 15, 4618–4621

 

Exploiting Carvone To Demonstrate Both Stereocontrol and Regiocontrol: 1,2‑ vs 1,4‑Addition of Grignard Reagents and Organocuprates

Authors: Thai Phat Truong, Sophia J. Bailey, Alexandra E. Golliher, Erika Y. Monroy, Uttar K. Shrestha, William A. Maio

J. Chem. Educ. 2018, 95, 3, 438–444


Undergraduate Research (2013 ‑ 2017)

Proteopedia entry: G‑protein coupled receptors

 

Authors: R. Jeremy Johnson, Jacob Applegarth, Steven Bennett, Sydney Caskey, Connor Coatney, Kurt Corsbie, Allison Cotter, Daniel Cotter, Alexis Coulis, Heather Hansen, Whitney Hart, Cutter Koehler, Andrew Koelper, Stephanie Kuhlman, Chandler Mitchell, Blake Moskal, Olivia Murfield, Allie Paton, Daniel Schemenauer, Brittany Stankavich, Clayton Taylor, Brent Waibel, L. Dean Williams

Biochem. Mol. Biol. Educ., 2017, 45, 277–278