{"id":4832,"date":"2023-09-09T11:39:54","date_gmt":"2023-09-09T15:39:54","guid":{"rendered":"https:\/\/sas.rochester.edu\/chm\/groups\/partridge\/?p=4832"},"modified":"2024-08-08T06:40:29","modified_gmt":"2024-08-08T10:40:29","slug":"liz-chaperone-paper","status":"publish","type":"post","link":"https:\/\/sas.rochester.edu\/chm\/groups\/partridge\/liz-chaperone-paper\/","title":{"rendered":"Liz&#8217;s chaperone paper is published!"},"content":{"rendered":"<p>The group&#8217;s first publication is out now in\u00a0<a href=\"https:\/\/doi.org\/10.1039\/D3CB00086A\"><em>RSC Chemical Biology<\/em><\/a>, in which we report the discovery of a series of amphiphilic dendrons that exhibit holdase chaperone activity! In this proof-of-concept study led by graduate student Liz Piedmont, we show that deliberate molecular design can be used to tune the solubility of these amphiphiles, leading to their assembly into monodisperse nanostructures that reduce the extent of amyloid fibrillation. Many thanks to our collaborators in <a href=\"https:\/\/www.krausslab.com\/\">Todd Krauss&#8217; group<\/a> for the AFM measurements, and thanks too to\u00a0<em>RSC Chemical Biology<\/em> for the invitation to be part of the <a href=\"https:\/\/pubs.rsc.org\/en\/journals\/articlecollectionlanding?sercode=cb&amp;themeid=4774b1bf-b747-4805-bb95-1ccb5f9670ab\">2023 Emerging Investigators<\/a> Collection!<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The group&#8217;s first publication is out now in\u00a0RSC Chemical Biology, in which we report the discovery of a series of amphiphilic dendrons that exhibit holdase chaperone activity! In this proof-of-concept&hellip;<\/p>\n","protected":false},"author":26,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4832","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Liz&#039;s chaperone paper is published! - Partridge Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sas.rochester.edu\/chm\/groups\/partridge\/liz-chaperone-paper\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Liz&#039;s chaperone paper is published! - Partridge Group\" \/>\n<meta property=\"og:description\" content=\"The group&#8217;s first publication is out now in\u00a0RSC Chemical Biology, in which we report the discovery of a series of amphiphilic dendrons that exhibit holdase chaperone activity! 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