The group’s first publication is out now in RSC Chemical Biology, in which we report the discovery of a series of amphiphilic dendrons that exhibit holdase chaperone activity! In this proof-of-concept study led by graduate student Liz Piedmont, we show that deliberate molecular design can be used to tune the solubility of these amphiphiles, leading to their assembly into monodisperse nanostructures that reduce the extent of amyloid fibrillation. Many thanks to our collaborators in Todd Krauss’ group for the AFM measurements, and thanks too to RSC Chemical Biology for the invitation to be part of the 2023 Emerging Investigators Collection!
