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We are an international team of scientists driven to find molecular mechanisms to extend human health- and lifespan.
We study comparative biology of aging, genomic stability, and epigenetics of aging
Dr. Gorbunova and Dr. Seluanov
We are an international team of scientists driven to find molecular mechanisms to extend human health- and lifespan.
Our research is focused on Aging, DNA repair, and Cancer.
Aging is one of the biggest mysteries of biology. Aging is associated in accumulation of mutations and genomic instability. We study age-related changes in repair of DNA double-strand breaks using human cells and transgenic mice. We are also using comparative approach to study aging by analyzing short- and long-lived animal species. Finally, as aging is associated with increased cancer incidence, we study DNA repair in breast cancer cells, and anti-cancer mechanisms in short- and long-lived rodents.
We publish our research in top journals.
Morandini F, Seluanov A, Gorbunova V. Slow and steady lives the longest. Nature Aging, 2024
Paine PT, Rechsteiner C, Morandini F, …, Seluanov A, Gorbunova V, Ocampo A. Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging. Frontiers in Aging, 2024.
Brosh RB, Moskalev A, Gorbunova V. DNA repair and interventions in aging. Frontiers in Aging, 2023.
Zhao Y, Zheng Z, Zhang Z, Xu Y, Hillpot E, Lin YS, Zakusilo FT, Lu JY, Ablaeva J, Biashad SA, Miller RA, Nevo E, Seluanov A, Gorbunova V. Evolution of high-molecular-mass hyaluronic acid is associated with subterranean lifestyle. Nature Communications, 2023.
Romanenko SA, …, Seluanov A, Gorbunova V, Azpurua J, Pereira JC, Ferguson-Smith MA, Graphodatsky AS. Integration of fluorescence in situ hybridization and chromosome-length genome assemblies revealed synteny map for guinea pig, naked mole-rat, and human. Scientific Reports, 2023.