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C. Rose Kennedy

she/her/hers

James P. Wilmot Distinguished Assistant Professor in the Department of Chemistry

Assistant Professor of Chemistry

PhD, Harvard University, 2017

Office Location
459 Hutchison Hall
Telephone
(585) 275-8778
Web Address
Website

Research Overview

Research in the Kennedy group is directed toward the development of sustainable chemo-, regio-, and stereoselective catalytic methods for the valorization of chemical feedstock (ranging from petrochemicals to biomass to anthropogenic waste) to produce useful building blocks and materials for applications in chemical synthesis (e.g. therapeutics, flavors and fragrances, agrochemicals, materials etc.) Strategies to achieve these goals draw from the complementary strengths of organometallic chemistry and organocatalysis. Particular emphasis is placed on (i) rational manipulation of attractive secondary coordination sphere interactions to achieve precise control over competing reaction pathways and (ii) reversible application of external stimuli to govern reactivity and selectivity. This work relies heavily on catalyst design driven by insights gleaned from mechanistic elucidation. These pursuits lie at the interface of synthetic organic and organometallic chemistry, and they draw from state-of-the-art experimental and computational techniques in physical organic and inorganic chemistry. Students will gain experience and expertise in organic and organometallic synthesis and characterization, method development, and mechanistic study.

Research Interests

  • Catalysis and Synthetic Methods
  • Organometallic Chemistry
  • Mechanistic and Physical Organic Chemistry

Selected Publications

  • Afandiyeva, M. ‡; Wu, Xijue†,‡; Brennessel, W. W.; Kadam, A. A.; Kennedy, C. R.* Secondary-Sphere Preorganization Enables Nickel-Catalyzed Nitrile Hydroboration. Chem. Commun. 2023, 59, 13450–13453. DOI: 10.1039/D3CC04229D (Invited for 2023 Emerging Investigators Collection)
  • Malyk, K. R.‡ ; Pillai, V. G.‡ ; Brennessel, W. W.; Leon Baxin, R.; Silk, E. S. †; Nakamura, D. T. †; Kennedy, C. R.* Distinguishing Competing Mechanistic Manifolds for C(acyl)–N Functionalization by a Ni/N-Heterocyclic Carbene Catalyst System. JACS Au. 2023, 3, 2451–2457. DOI: 10.1021/jacsau.3c00283
  • Hanaway, D. H.†; Kennedy, C. R.* An Automated Variable Electric-Field DFT Application for Evaluation of Optimally Oriented Electric Fields on Chemical Reactivity. J. Org. Chem. 202388, 106–115. DOI: 10.1021/acs.joc.2c01893
  • Afandiyeva, M. A.‡; Kadam, A. A.‡; Wu, X.†,‡; Brennessel, W. W.; Kennedy, C. R.* Synthesis, Structure, and Hydroboration Reactivity of Anionic Nickel(0) Complexes Supported by Bidentate NHC-Pyridone Ligands. Organometallics202221, 3014–3023. DOI: 10.1021/acs.organomet.2c00439  (Selected as ACS Editors’ Choice; Top 3 Most-Read Papers)

(‡ Equal contributions. § Undergraduate coauthor.)